Role of Renal Drug Exposure in Polymyxin B-Induced Nephrotoxicity
نویسندگان
چکیده
منابع مشابه
Pharmacogenetics and drug-induced nephrotoxicity in renal transplant recipients
INTRODUCTION The advent of calcineurin inhibitors (CNIs), as the leading immunosuppressive agents, not only has revolutionized the transplant medicine but also made it a better therapeutic intervention that guarantees the graft outcome and improves the survival rate of patients. However, genetic polymorphism(s) in the CNIs metabolic substrates genes (CYP3A4, CYP3A5) and their transporter such a...
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In the present review we have attempted to assess the involvement of the organic anion transporters OAT1, OAT2, OAT3, and OAT4, belonging to the SLC22 family of polyspecific carriers, in drug-induced renal damage in humans. We have focused on drugs with widely recognized nephrotoxic potential, which have previously been reported to interact with OAT family members, and whose underlying pathogen...
متن کاملRenal drug transporters and nephrotoxicity
Among drug-induced renal failure, direct renal tubular toxicity, typically described as toxic acute tubular necrosis, is often associated with increased cellular uptake of nephrotoxic compounds. Drug transporters in tubular cells are the first fundamental stage in the development of the nephrotoxic process. Several examples can be given of organic substances that are nephrotoxic only after bein...
متن کاملRisk factors for nephrotoxicity onset associated with polymyxin B therapy.
OBJECTIVES Polymyxin B is an active agent against many MDR Gram-negative bacteria, but nephrotoxicity is a major hindrance to its widespread use. To guide its optimal use, we determined the risk factors for nephrotoxicity onset associated with polymyxin B. METHODS In a multicentre, retrospective, cohort study, we evaluated adult patients with normal renal function who received ≥72 h of polymy...
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Polymyxins have a long history of dose-limiting toxicity, but the underlying mechanism of polymyxin B-induced nephrotoxicity is unclear. This study investigated the link between the nephrotoxic effects of polymyxin B on renal metabolic functions and mitochondrial morphology in rats and on the structural integrity of LLC-PK1 cells. Fifteen Wistar rats were divided into two groups: Saline group, ...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2017
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.02391-16